Reactome | MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter

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MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter Show undefined attributes

authored	[InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8943816] Orlic-Milacic, Marija, 2016-10-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8943816] Orlic-Milacic, Marija, 2016-10-30
dbId	8943817
displayName	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
input	[Complex:R-HSA-8943810] MECOM:PTEN gene [nucleoplasm] [CandidateSet:R-HSA-8943822] PRC1.4,PRC2 (EZH2) core [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8942920] Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins [LiteratureReference:8942922] The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter
orthologousEvent	[Reaction:R-CEL-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Caenorhabditis elegans [Reaction:R-DME-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Drosophila melanogaster [Reaction:R-GGA-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Gallus gallus [Reaction:R-SSC-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Sus scrofa [Reaction:R-BTA-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Bos taurus [Reaction:R-CFA-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Canis familiaris [Reaction:R-RNO-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Rattus norvegicus [Reaction:R-MMU-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Mus musculus
output	[Complex:R-HSA-8943821] MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8943811] MECOM (EVI1) binds the PTEN gene promoter - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8943817
summation	[Summation:8943902] The transcription factor MECOM (EVI1) can associate with the...

Referrals

(hasEvent)	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN