Reactome | SALL4 recruits NuRD to PTEN gene

Schema > Reaction > Entries

SALL4 recruits NuRD to PTEN gene Show undefined attributes

authored	[InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8943779] Orlic-Milacic, Marija, 2016-10-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8943779] Orlic-Milacic, Marija, 2016-10-29
dbId	8943780
displayName	SALL4 recruits NuRD to PTEN gene
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
input	[Complex:R-HSA-4657018] NuRD complex [nucleoplasm] [Complex:R-HSA-8943729] SALL4:PTEN gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:994203] Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex [LiteratureReference:8943798] Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SALL4 recruits NuRD to PTEN gene
orthologousEvent	[Reaction:R-CEL-8943780] SALL4 recruits NuRD to PTEN gene - Caenorhabditis elegans [Reaction:R-DME-8943780] SALL4 recruits NuRD to PTEN gene - Drosophila melanogaster [Reaction:R-GGA-8943780] SALL4 recruits NuRD to PTEN gene - Gallus gallus [Reaction:R-XTR-8943780] SALL4 recruits NuRD to PTEN gene - Xenopus tropicalis [Reaction:R-DRE-8943780] SALL4 recruits NuRD to PTEN gene - Danio rerio [Reaction:R-SSC-8943780] SALL4 recruits NuRD to PTEN gene - Sus scrofa [Reaction:R-BTA-8943780] SALL4 recruits NuRD to PTEN gene - Bos taurus [Reaction:R-CFA-8943780] SALL4 recruits NuRD to PTEN gene - Canis familiaris [Reaction:R-RNO-8943780] SALL4 recruits NuRD to PTEN gene - Rattus norvegicus [Reaction:R-MMU-8943780] SALL4 recruits NuRD to PTEN gene - Mus musculus
output	[Complex:R-HSA-8943781] SALL4:NuRD:PTEN gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8943728] SALL4 binds the PTEN gene promoter - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8943780
summation	[Summation:8943794] SALL4 recruits the transcriptional repressor complex NuRD, c...

Referrals

(hasEvent)	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN