Reactome | NR2E1 associated with transcription repressors binds PTEN promoter

Schema > Reaction > Entries

NR2E1 associated with transcription repressors binds PTEN promoter Show undefined attributes

authored	[InstanceEdit:6807125] Orlic-Milacic, Marija, 2015-10-29 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6807080] Orlic-Milacic, Marija, 2015-10-29
dbId	6807077
displayName	NR2E1 associated with transcription repressors binds PTEN promoter
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
inferredFrom	[Reaction:R-MMU-6807090] Nr2e1 binds Pten promoter - Mus musculus
input	[Complex:R-HSA-6807075] NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5632949] PTEN gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6807074] Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1 [LiteratureReference:6808473] Transrepressive function of TLX requires the histone demethylase LSD1 [LiteratureReference:6808475] Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NR2E1 associated with transcription repressors binds PTEN promoter
output	[Complex:R-HSA-6807085] NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807077
summation	[Summation:6807076] NR2E1 (TLX) associated with transcription repressors binds t...

Referrals

(hasEvent)	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
(inferredTo)	[Reaction:R-MMU-6807090] Nr2e1 binds Pten promoter

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