Regulation of PTEN gene transcription

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Homo sapiens
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Transcription of the PTEN gene is regulated at multiple levels. Epigenetic repression involves the recruitment of Mi-2/NuRD upon SALL4 binding to the PTEN promoter (Yang et al. 2008, Lu et al. 2009) or EVI1-mediated recruitment of the polycomb repressor complex (PRC) to the PTEN promoter (Song et al. 2009, Yoshimi et al. 2011). Transcriptional regulation is also elicited by negative regulators, including NR2E1:ATN1 (atrophin-1) complex, JUN (c-Jun), SNAIL and SLUG (Zhang et al. 2006, Vasudevan et al. 2007, Escriva et al. 2008, Uygur et al. 2015) and positive regulators such as TP53 (p53), MAF1, ATF2, EGR1 or PPARG (Stambolic et al. 2001, Virolle et al. 2001, Patel et al. 2001, Shen et al. 2006, Li et al. 2016).

Literature References
PubMed ID Title Journal Year
21289308 Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

Sato, T, Nitta, E, Kitamura, T, Yoshimi, A, Shimabe, M, Yoshiki, Y, Goyama, S, Arai, S, Nannya, Y, Kurokawa, M, Nakagawa, M, Imai, Y, Watanabe-Okochi, N

Blood 2011
19884659 The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

Huang, WL, Li, J, Feng, Y, Xia, YF, Shi, QH, Tsao, SW, Liu, WL, Zeng, YX, Yu, CP, Li, M, Kang, TB, Song, LB, Band, V, Zeng, MS, Band, H, Liao, WT, Kong, QL, Zhang, L, Li, MZ, Fu, LW, Zhang, X, Xu, LH, Hu, LJ

J. Clin. Invest. 2009
16702404 Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

Zhang, CL, Zou, Y, Gage, FH, Evans, RM, Yu, RT

Genes Dev. 2006
18172008 Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis

Gridley, T, Murray, SA, García de Herreros, A, Herranz, N, Dave, N, Virtanen, I, Peiró, S, Montserrat-Sentís, B, Escrivà, M, Villagrasa, P, Francí, C

Mol. Cell. Biol. 2008
11545734 Regulation of PTEN transcription by p53

Stambolic, V, Sas, D, Benchimol, S, Snow, B, Jang, Y, MacPherson, D, Lin, Y, Mak, TW

Mol. Cell 2001
11378386 Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN

Downes, CP, Patel, L, MacPhee, CH, Coxon, P, Pass, I, Smith, SA

Curr. Biol. 2001
26910647 MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription

Zheng, XF, Huang, W, Li, M, Fu, L, Li, XX, Wang, HY, Yang, Y, Li, Y, Wang, S, Tsang, CK

Hepatology 2016
11781575 The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

Baron, V, Virolle, T, Mustelin, T, Birle, D, Adamson, ED, de Belle, I, Mercola, D

Nat. Cell Biol. 2001
16418168 Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells

Wang, J, Shen, YH, LeMaire, SA, Wang, XL, Coselli, JS, Gan, Y, Zhang, L, Wang, X

J. Biol. Chem. 2006
17974977 Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras

Burikhanov, R, Vasudevan, KM, Goswami, A, Rangnekar, VM

Cancer Res. 2007
19440552 Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex

Jeong, HW, Silberstein, LE, Carroll, J, Chai, L, Yang, Y, Kong, N, Lu, J, Luo, HR, Yupoma, LE

PLoS One 2009
18487508 SALL4 is a key regulator of survival and apoptosis in human leukemic cells

Ma, Y, Alipio, Z, Ward, DC, Xu, D, Dang, H, Gao, C, Yang, J, Chai, L, Fowles, TC, Fink, LM

Blood 2008
25728608 SLUG is a direct transcriptional repressor of PTEN tumor suppressor

Liaw, L, Leikina, E, Wu, WS, Vary, C, Abramo, K, Uygur, B

Prostate 2015
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