Reactome | EGR1 binds the PTEN gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:6807125] Orlic-Milacic, Marija, 2015-10-29 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8944081] Orlic-Milacic, Marija, 2016-11-02
dbId	8944078
displayName	EGR1 binds the PTEN gene promoter
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5632949] PTEN gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8943330] The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1 binds the PTEN gene promoter
output	[Complex:R-HSA-8944084] EGR1:PTEN gene [nucleoplasm]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8944078
summation	[Summation:8944079] In response to UV-induced DNA damage, expresion levels of bo...

(hasEvent)	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN

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