Reactome | mTORC1 phosphorylates MAF1

Schema > Reaction > Entries

mTORC1 phosphorylates MAF1 Show undefined attributes

authored	[InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8944393] Orlic-Milacic, Marija, 2016-11-03
catalystActivity	[CatalystActivity:8944450] protein serine/threonine kinase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8944459] Orlic-Milacic, Marija, 2016-11-03
dbId	8944454
displayName	mTORC1 phosphorylates MAF1
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8944457] MAF1 translocates to the nucleus - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-8944460] MAF1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8944428] Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells [LiteratureReference:8944437] mTORC1 directly phosphorylates and regulates human MAF1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	mTORC1 phosphorylates MAF1
orthologousEvent	[Reaction:R-DDI-8944454] mTORC1 phosphorylates MAF1 - Dictyostelium discoideum [Reaction:R-CEL-8944454] mTORC1 phosphorylates MAF1 - Caenorhabditis elegans [Reaction:R-DME-8944454] mTORC1 phosphorylates MAF1 - Drosophila melanogaster [Reaction:R-GGA-8944454] mTORC1 phosphorylates MAF1 - Gallus gallus [Reaction:R-DRE-8944454] mTORC1 phosphorylates MAF1 - Danio rerio [Reaction:R-SSC-8944454] mTORC1 phosphorylates MAF1 - Sus scrofa [Reaction:R-BTA-8944454] mTORC1 phosphorylates MAF1 - Bos taurus [Reaction:R-CFA-8944454] mTORC1 phosphorylates MAF1 - Canis familiaris [Reaction:R-RNO-8944454] mTORC1 phosphorylates MAF1 - Rattus norvegicus [Reaction:R-MMU-8944454] mTORC1 phosphorylates MAF1 - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8944455] p-S60,S68,S75-MAF1 [cytosol]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8944454
summation	[Summation:8944451] Activated mTORC1 complex phosphorylates the transcription fa...

Referrals

(hasEvent)	[Pathway:R-HSA-8943724] Regulation of PTEN gene transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8944457] MAF1 translocates to the nucleus