Reactome | Formation of CDK4/6:CCND complexes

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Formation of CDK4/6:CCND complexes Show undefined attributes

authored	[InstanceEdit:182570] Matthews, L, 2006-07-03 08:41:56
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8941897] Orlic-Milacic, Marija, 2016-10-07
dbId	8941895
deleted	[Deleted:8949932] Deletion of instance: 69213
displayName	Formation of CDK4/6:CCND complexes
edited	[InstanceEdit:182570] Matthews, L, 2006-07-03 08:41:56 [InstanceEdit:8941900] Orlic-Milacic, Marija, 2016-10-07
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
followingEvent	[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Homo sapiens [Reaction:R-HSA-9008412] CDK4 phosphorylates RUNX2 - Homo sapiens [BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
input	[DefinedSet:R-HSA-69209] CDK4,CDK6 [cytosol] [CandidateSet:R-HSA-182700] Cyclin D [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77490] New functional activities for the p21 family of CDK inhibitors. [LiteratureReference:8941906] P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes [LiteratureReference:8941907] Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors [LiteratureReference:8941977] Identification of G1 kinase activity for cdk6, a novel cyclin D partner [LiteratureReference:8941974] Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins [LiteratureReference:8942875] Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1) [LiteratureReference:8942869] Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1) [LiteratureReference:8949552] Regulation of CDK4 [LiteratureReference:8949545] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) [LiteratureReference:8949555] A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes [LiteratureReference:8949553] CDK inhibitors: positive and negative regulators of G1-phase progression
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Formation of CDK4/6:CCND complexes
orthologousEvent	[Reaction:R-SPO-8941895] Formation of CDK4/6:CCND complexes - Schizosaccharomyces pombe [Reaction:R-DDI-8941895] Formation of CDK4/6:CCND complexes - Dictyostelium discoideum [Reaction:R-CEL-8941895] Formation of CDK4/6:CCND complexes - Caenorhabditis elegans [Reaction:R-DME-8941895] Formation of CDK4/6:CCND complexes - Drosophila melanogaster [Reaction:R-GGA-8941895] Formation of CDK4/6:CCND complexes - Gallus gallus [Reaction:R-XTR-8941895] Formation of CDK4/6:CCND complexes - Xenopus tropicalis [Reaction:R-DRE-8941895] Formation of CDK4/6:CCND complexes - Danio rerio [Reaction:R-SSC-8941895] Formation of CDK4/6:CCND complexes - Sus scrofa [Reaction:R-BTA-8941895] Formation of CDK4/6:CCND complexes - Bos taurus [Reaction:R-CFA-8941895] Formation of CDK4/6:CCND complexes - Canis familiaris [Reaction:R-RNO-8941895] Formation of CDK4/6:CCND complexes - Rattus norvegicus [Reaction:R-MMU-8941895] Formation of CDK4/6:CCND complexes - Mus musculus
output	[Complex:R-HSA-8941896] CDK4,CDK6:CCND [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-8853956] Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 - Homo sapiens [BlackBoxEvent:R-HSA-9623355] ESR1-dependent CCND1 expression - Homo sapiens [BlackBoxEvent:R-HSA-9009378] Estrogen-responsive CCND1 gene expression - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-182599] Negative regulation by 'CDK4,CDK6:INK4 [cytosol]'
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942662] D'Eustachio, Peter, 2016-10-19 [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8941895
summation	[Summation:8941910] The cyclin-dependent kinase CDK4 or CDK6 forms a complex wit...
updateTrackers	[UpdateTracker:9781579] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v60:[addLiteratureReference, modifyText] [UpdateTracker:9953681] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v93:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781579] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v60:[addLiteratureReference, modifyText] [UpdateTracker:9953681] Update Tracker - [Reaction:8941895] Formation of CDK4/6:CCND complexes - v93:[modifyText]
(replacementInstances)	[Deleted:8949932] Deletion of instance: 69213
(precedingEvent)	[Reaction:R-HSA-9008412] CDK4 phosphorylates RUNX2 [BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
(hasEvent)	[Pathway:R-HSA-69231] Cyclin D associated events in G1

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