Reactome | Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus

Schema > BlackBoxEvent > Entries

Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus Show undefined attributes

authored	[InstanceEdit:8942806] Orlic-Milacic, Marija, 2016-10-20
category	omitted
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:8942806] Orlic-Milacic, Marija, 2016-10-20
dbId	8942803
deleted	[Deleted:8949938] Deletion of instance: 141299
displayName	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
edited	[InstanceEdit:182603] Matthews, L, 2006-07-10 19:20:13 [InstanceEdit:8949902] Orlic-Milacic, Marija, 2016-11-30
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
followingEvent	[Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Homo sapiens
input	[CandidateSet:R-HSA-8949872] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77490] New functional activities for the p21 family of CDK inhibitors. [LiteratureReference:8942814] Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4 [LiteratureReference:8942828] Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition [LiteratureReference:8942769] Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control [LiteratureReference:8949865] The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2 [LiteratureReference:8949861] Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry [LiteratureReference:8949867] Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells [LiteratureReference:8941906] P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
orthologousEvent	[BlackBoxEvent:R-SPO-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Dictyostelium discoideum [BlackBoxEvent:R-CEL-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Gallus gallus [BlackBoxEvent:R-XTR-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Xenopus tropicalis [BlackBoxEvent:R-DRE-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Danio rerio [BlackBoxEvent:R-SSC-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Sus scrofa [BlackBoxEvent:R-BTA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Bos taurus [BlackBoxEvent:R-CFA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Canis familiaris [BlackBoxEvent:R-RNO-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Mus musculus
output	[CandidateSet:R-HSA-8949874] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Homo sapiens [Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens [Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Homo sapiens [Reaction:R-HSA-8848436] PTK6 phosphorylates CDKN1B - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8942803
summation	[Summation:8942804] Cyclin D:CDK4/6 complexes translocate to the nucleus from th...

Referrals

(replacementInstances)	[Deleted:8949938] Deletion of instance: 141299
(hasEvent)	[Pathway:R-HSA-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6

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