Reactome | Formation of CDK4/6:CCND complexes

Schema > Reaction > Entries

Formation of CDK4/6:CCND complexes Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10716708
displayName	Formation of CDK4/6:CCND complexes
eventOf	[Pathway:R-XTR-69231] Cyclin D associated events in G1 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9008412] CDK4 phosphorylates RUNX2 - Xenopus tropicalis [Reaction:R-XTR-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Xenopus tropicalis [BlackBoxEvent:R-XTR-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-68328] ccnd1 [cytosol] [DefinedSet:R-XTR-69209] CDK4,CDK6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of CDK4/6:CCND complexes
output	[Complex:R-XTR-8941896] CDK4,CDK6:CCND [cytosol]
regulatedBy	[NegativeRegulation:10716709] Negative regulation by 'CDK4,CDK6:INK4 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8941895
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-XTR-9008412] CDK4 phosphorylates RUNX2 [BlackBoxEvent:R-XTR-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [Reaction:R-XTR-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
(hasEvent)	[Pathway:R-XTR-69231] Cyclin D associated events in G1
(inferredTo)	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes