Reactome | Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes

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Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes Show undefined attributes

authored	[InstanceEdit:182570] Matthews, L, 2006-07-03 08:41:56
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8941916] Orlic-Milacic, Marija, 2016-10-07
dbId	8941915
displayName	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
edited	[InstanceEdit:8941980] Orlic-Milacic, Marija, 2016-10-07
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
followingEvent	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Homo sapiens [BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
input	[Complex:R-HSA-8941896] CDK4,CDK6:CCND [cytosol] [CandidateSet:R-HSA-8941923] CDKN1A,CDKN1B,(CDKN1C) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77490] New functional activities for the p21 family of CDK inhibitors. [LiteratureReference:8941906] P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes [LiteratureReference:8941907] Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors [LiteratureReference:8942788] Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements [LiteratureReference:8949552] Regulation of CDK4 [LiteratureReference:8942689] Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
orthologousEvent	[Reaction:R-CEL-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Caenorhabditis elegans [Reaction:R-DME-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Drosophila melanogaster [Reaction:R-GGA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Gallus gallus [Reaction:R-XTR-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Xenopus tropicalis [Reaction:R-DRE-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Danio rerio [Reaction:R-SSC-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Sus scrofa [Reaction:R-BTA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Bos taurus [Reaction:R-CFA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Canis familiaris [Reaction:R-RNO-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Rattus norvegicus [Reaction:R-MMU-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Mus musculus
output	[Complex:R-HSA-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]
precedingEvent	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942662] D'Eustachio, Peter, 2016-10-19 [InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8941915
summation	[Summation:8941929] Binding of CDK inhibitors of the Cip/Kip family, CDKNA1 (p21...
updateTrackers	[UpdateTracker:9781808] Update Tracker - [Reaction:8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - v60:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781808] Update Tracker - [Reaction:8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - v60:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes [BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus

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