Reactome | CDK4 phosphorylates RUNX2

Schema > Reaction > Entries

CDK4 phosphorylates RUNX2 Show undefined attributes

authored	[InstanceEdit:9008414] Orlic-Milacic, Marija, 2017-06-09
catalystActivity	[CatalystActivity:9008413] cyclin-dependent protein serine/threonine kinase activity of CDK4:CCND1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9008414] Orlic-Milacic, Marija, 2017-06-09
dbId	9008412
displayName	CDK4 phosphorylates RUNX2
edited	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
eventOf	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
followingEvent	[Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter - Homo sapiens [Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-8865420] RUNX2:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9008431] Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CDK4 phosphorylates RUNX2
orthologousEvent	[Reaction:R-CEL-9008412] CDK4 phosphorylates RUNX2 - Caenorhabditis elegans [Reaction:R-DME-9008412] CDK4 phosphorylates RUNX2 - Drosophila melanogaster [Reaction:R-XTR-9008412] CDK4 phosphorylates RUNX2 - Xenopus tropicalis [Reaction:R-DRE-9008412] CDK4 phosphorylates RUNX2 - Danio rerio [Reaction:R-SSC-9008412] CDK4 phosphorylates RUNX2 - Sus scrofa [Reaction:R-BTA-9008412] CDK4 phosphorylates RUNX2 - Bos taurus [Reaction:R-CFA-9008412] CDK4 phosphorylates RUNX2 - Canis familiaris [Reaction:R-MMU-9008412] CDK4 phosphorylates RUNX2 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9008410] p-S451-RUNX2:CBFB [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865425] RUNX2 binds CBFB - Homo sapiens [Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9008412
summation	[Summation:9008425] In endothelial cells, in response to high glucose, probably ...

Referrals

(hasEvent)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
(precedingEvent)	[Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter [Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter