Reactome | Estrogen-responsive CCND1 gene expression

Schema > BlackBoxEvent > Entries

Estrogen-responsive CCND1 gene expression Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009379] Rothfels, Karen, 2017-06-16
dbId	9009378
displayName	Estrogen-responsive CCND1 gene expression
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8853953] CCND1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009347] The elements of human cyclin D1 promoter and regulation involved [LiteratureReference:9009352] Transcriptional regulation of the cyclin D1 gene at a glance [LiteratureReference:9009325] Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions [LiteratureReference:9009005] Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter [LiteratureReference:9009368] Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element [LiteratureReference:9009355] Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements [LiteratureReference:9009340] The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Estrogen-responsive CCND1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-68328] CCND1 [cytosol]
precedingEvent	[Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9009382] Positive gene expression regulation by 'CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9011946] Positive gene expression regulation by 'CCND1 gene:nucleosome:ESR1:ESTG [nucleoplasm]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9009378
summation	[Summation:9009354] The proliferative effects of estrogen stimulation arise in p...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes