Reactome | Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1

Schema > BlackBoxEvent > Entries

Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 Show undefined attributes

authored	[InstanceEdit:9652372] Orlic-Milacic, Marija, 2019-06-28
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8853954] Orlic-Milacic, Marija, 2016-01-25
dbId	8853956
displayName	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1
edited	[InstanceEdit:9666043] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX - Homo sapiens
followingEvent	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8853953] CCND1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8853958] VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor [LiteratureReference:8853951] The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway [LiteratureReference:8853942] Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1
output	[EntityWithAccessionedSequence:R-HSA-68328] CCND1 [cytosol]
precedingEvent	[Reaction:R-HSA-8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:8853948] Positive gene expression regulation by 'CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8853961] Negative gene expression regulation by 'VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641770] Positive gene expression regulation by 'CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]' Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells [RegulationReference:9642163] Negative gene expression regulation by 'VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm]' VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666044] Vegi, Naidu M, 2019-10-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8853956
summation	[Summation:8867918] While the complex of beta-catenin (CTNNB1) and TCF4/LEF1 tra...

Referrals

(hasEvent)	[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX
(precedingEvent)	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes

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