Reactome | p-BRAF L597R [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9648632] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9648595] COSMIC:COSV56121113
dbId	9648631
disease	[Disease:1614289] melanoma [Disease:4791250] colorectal cancer
displayName	p-BRAF L597R [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602 [ReplacedResidue:9648600] L-leucine 597 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:9648578] Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma [LiteratureReference:9648517] Acquired/intratumoral mutation of KRAS during metastatic progression of colorectal carcinogenesis
maxDepth	1
modified	[InstanceEdit:9648998] Rothfels, Karen, 2019-06-10
name	p-BRAF L597R B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648631
startCoordinate	2

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