Reactome | p-BRAF N581S [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9648865] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:9648847] COSMIC:COSV56058108
dbId	9648866
disease	[Disease:1614289] melanoma [Disease:9648849] histiocytic and dendritic cell cancer [Disease:4791250] colorectal cancer
displayName	p-BRAF N581S [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602 [ReplacedResidue:9648848] L-asparagine 581 replaced with L-serine
inDisease	true
literatureReference	[LiteratureReference:9648829] Somatic mutations in histiocytic sarcoma identified by next generation sequencing [LiteratureReference:9648762] Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma [LiteratureReference:9648756] Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
modified	[InstanceEdit:9648999] Rothfels, Karen, 2019-06-10
name	p-BRAF N581S B-RAF
referenceEntity	[ReferenceGeneProduct:58251] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648866
startCoordinate	2

(hasCandidate)