Reactome | p-BRAF G466A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9648632] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:12020755] Mondo:0008903 [DatabaseIdentifier:9648588] COSMIC:COSV56070593
dbId	9648629
disease	[Disease:4791250] colorectal cancer [Disease:1500699] lung cancer
displayName	p-BRAF G466A [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:9648598] glycine 466 replaced with L-alanine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
maxDepth	1
modified	[InstanceEdit:9648992] Rothfels, Karen, 2019-06-10
name	p-BRAF G466A B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648629
startCoordinate	2

(hasCandidate)

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