Reactome | RET signaling

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RET signaling Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
created	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
dbId	8853659
displayName	RET signaling
doi	10.3180/R-HSA-8853659.2
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-422475] Axon guidance - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8853745] RET binds GFRA1,GFRA3 - Homo sapiens [Reaction:R-HSA-8871226] RET binds GFRA1,GFRA2 - Homo sapiens [Reaction:R-HSA-8871227] RET binds GFRA4 - Homo sapiens [Reaction:R-HSA-8853789] GDNF,NRTN bind RET:GFRA1,GFRA2 - Homo sapiens [Reaction:R-HSA-8853800] ARTN binds RET:GFRA1,GFRA3 - Homo sapiens [Reaction:R-HSA-8853801] PSPN binds RET:GFRA4 - Homo sapiens [Reaction:R-HSA-8853762] RET dimerizes - Homo sapiens [Reaction:R-HSA-8853792] RET tyrosine phosphorylation - Homo sapiens [Reaction:R-HSA-8854908] PKA phosphorylates RET:GDNF:GFRA dimer - Homo sapiens [Reaction:R-HSA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Homo sapiens [Reaction:R-HSA-8855915] 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors - Homo sapiens [Reaction:R-HSA-8855564] 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 - Homo sapiens [Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Homo sapiens [BlackBoxEvent:R-HSA-8854981] SHC1 in the RET complex is phosphorylated - Homo sapiens [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens [BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens [BlackBoxEvent:R-HSA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Homo sapiens [BlackBoxEvent:R-HSA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Homo sapiens [BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Homo sapiens [Reaction:R-HSA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Homo sapiens [Reaction:R-HSA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Homo sapiens [Reaction:R-HSA-8853755] 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 - Homo sapiens [Reaction:R-HSA-8855747] 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:8853831] RET and neuroendocrine tumors [LiteratureReference:8853848] RET and neuroendocrine tumors
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RET signaling
orthologousEvent	[Pathway:R-CEL-8853659] RET signaling - Caenorhabditis elegans [Pathway:R-DME-8853659] RET signaling - Drosophila melanogaster [Pathway:R-GGA-8853659] RET signaling - Gallus gallus [Pathway:R-XTR-8853659] RET signaling - Xenopus tropicalis [Pathway:R-DRE-8853659] RET signaling - Danio rerio [Pathway:R-SSC-8853659] RET signaling - Sus scrofa [Pathway:R-BTA-8853659] RET signaling - Bos taurus [Pathway:R-CFA-8853659] RET signaling - Canis familiaris [Pathway:R-RNO-8853659] RET signaling - Rattus norvegicus [Pathway:R-MMU-8853659] RET signaling - Mus musculus
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8853659
summation	[Summation:8853581] The RET proto-oncogene encodes a receptor tyrosine kinase ex...
updateTrackers	[UpdateTracker:9780599] Update Tracker - [Pathway:8853659] RET signaling - v62:[removeHasEvent] [UpdateTracker:9782404] Update Tracker - [Pathway:8853659] RET signaling - v59:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9780599] Update Tracker - [Pathway:8853659] RET signaling - v62:[removeHasEvent] [UpdateTracker:9782404] Update Tracker - [Pathway:8853659] RET signaling - v59:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-422475] Axon guidance

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