Reactome | RET signaling

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RET signaling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445822
displayName	RET signaling
eventOf	[Pathway:R-BTA-422475] Axon guidance - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-8853745] RET binds GFRA1,GFRA3 - Bos taurus [Reaction:R-BTA-8871226] RET binds GFRA1,GFRA2 - Bos taurus [Reaction:R-BTA-8871227] RET binds GFRA4 - Bos taurus [Reaction:R-BTA-8853789] GDNF,NRTN bind RET:GFRA1,GFRA2 - Bos taurus [Reaction:R-BTA-8853800] ARTN binds RET:GFRA1,GFRA3 - Bos taurus [Reaction:R-BTA-8853801] PSPN binds RET:GFRA4 - Bos taurus [Reaction:R-BTA-8853762] RET dimerizes - Bos taurus [Reaction:R-BTA-8853792] RET tyrosine phosphorylation - Bos taurus [Reaction:R-BTA-8854908] PKA phosphorylates RET:GDNF:GFRA dimer - Bos taurus [Reaction:R-BTA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Bos taurus [Reaction:R-BTA-8855915] 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors - Bos taurus [Reaction:R-BTA-8855564] 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 - Bos taurus [Reaction:R-BTA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Bos taurus [BlackBoxEvent:R-BTA-8854981] SHC1 in the RET complex is phosphorylated - Bos taurus [Reaction:R-BTA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Bos taurus [Reaction:R-BTA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Bos taurus [BlackBoxEvent:R-BTA-8853793] p-5Y-RET complexes bind GRB2 - Bos taurus [BlackBoxEvent:R-BTA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Bos taurus [BlackBoxEvent:R-BTA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Bos taurus [BlackBoxEvent:R-BTA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Bos taurus [Reaction:R-BTA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Bos taurus [Reaction:R-BTA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Bos taurus [Reaction:R-BTA-8853755] 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 - Bos taurus [Reaction:R-BTA-8855747] 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP - Bos taurus
inferredFrom	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RET signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-8853659
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-422475] Axon guidance
(inferredTo)	[Pathway:R-HSA-8853659] RET signaling

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