Reactome | p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2

Schema > BlackBoxEvent > Entries

p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8854904] Jupe, Steve, 2016-01-29
dbId	8854897
displayName	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Homo sapiens
input	[DefinedSet:R-HSA-8854907] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] [DefinedSet:R-HSA-8855092] GAB1,GAB2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
orthologousEvent	[BlackBoxEvent:R-DME-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Drosophila melanogaster [BlackBoxEvent:R-GGA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Gallus gallus [BlackBoxEvent:R-XTR-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Danio rerio [BlackBoxEvent:R-SSC-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Sus scrofa [BlackBoxEvent:R-BTA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Bos taurus [BlackBoxEvent:R-CFA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Canis familiaris [BlackBoxEvent:R-RNO-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Rattus norvegicus [BlackBoxEvent:R-MMU-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Mus musculus
output	[Complex:R-HSA-8855090] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8854897
summation	[Summation:8853759] Grb-associated binder (GAB) proteins are a family of docking...

Referrals

(hasEvent)	[Pathway:R-HSA-8853659] RET signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated