Reactome | RET tyrosine phosphorylation

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RET tyrosine phosphorylation Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
catalystActivity	[CatalystActivity:8854772] transmembrane receptor protein tyrosine kinase activity of 2x RET:GFRA:GDNF complexes [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:8853732] Jupe, Steve, 2016-01-25
dbId	8853792
displayName	RET tyrosine phosphorylation
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Homo sapiens [Reaction:R-HSA-8853755] 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 - Homo sapiens [Reaction:R-HSA-8855915] 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors - Homo sapiens [Reaction:R-HSA-8855564] 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 - Homo sapiens [Reaction:R-HSA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Homo sapiens [Reaction:R-HSA-8855747] 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP - Homo sapiens [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Homo sapiens [BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens
input	[Complex:R-HSA-8853818] 2x RET:GFRA:GDNF complexes [plasma membrane] 30 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854857] Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RET tyrosine phosphorylation
orthologousEvent	[Reaction:R-GGA-8853792] RET tyrosine phosphorylation - Gallus gallus [Reaction:R-DRE-8853792] RET tyrosine phosphorylation - Danio rerio [Reaction:R-SSC-8853792] RET tyrosine phosphorylation - Sus scrofa [Reaction:R-BTA-8853792] RET tyrosine phosphorylation - Bos taurus [Reaction:R-CFA-8853792] RET tyrosine phosphorylation - Canis familiaris [Reaction:R-RNO-8853792] RET tyrosine phosphorylation - Rattus norvegicus [Reaction:R-MMU-8853792] RET tyrosine phosphorylation - Mus musculus
output	[Complex:R-HSA-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] 30 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-8853762] RET dimerizes - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853792
summation	[Summation:8853735] RET undergoes trans-autophosphorylation on specific tyrosine...
updateTrackers	[UpdateTracker:9782211] Update Tracker - [Reaction:8853792] RET tyrosine phosphorylation - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782211] Update Tracker - [Reaction:8853792] RET tyrosine phosphorylation - v59:[modifyText]
(precedingEvent)	[Reaction:R-HSA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 [Reaction:R-HSA-8853755] 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 [Reaction:R-HSA-8855915] 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors [Reaction:R-HSA-8855564] 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 [BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-HSA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 [Reaction:R-HSA-8855747] 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 [Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1
(hasEvent)	[Pathway:R-HSA-8853659] RET signaling

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