Reactome | 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6

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2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8855616] Jupe, Steve, 2016-02-04
dbId	8855617
displayName	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
input	[Complex:R-HSA-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [DefinedSet:R-HSA-8855619] DOK1,DOK2,DOK4,DOK5,DOK6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854835] Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation [LiteratureReference:8854842] Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6
orthologousEvent	[Reaction:R-GGA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Gallus gallus [Reaction:R-DRE-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Danio rerio [Reaction:R-SSC-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Sus scrofa [Reaction:R-BTA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Bos taurus [Reaction:R-CFA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Canis familiaris [Reaction:R-RNO-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Rattus norvegicus [Reaction:R-MMU-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Mus musculus
output	[Complex:R-HSA-8855573] 2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8853792] RET tyrosine phosphorylation - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8855617
summation	[Summation:8855618] Docking protein 1 (DOK 1), 2, 4, 5, and 6 adaptor proteins a...

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[Pathway:R-HSA-8853659] RET signaling

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