Reactome | SHC1 in the RET complex is phosphorylated

Schema > BlackBoxEvent > Entries

SHC1 in the RET complex is phosphorylated Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8854979] Jupe, Steve, 2016-01-29
dbId	8854981
displayName	SHC1 in the RET complex is phosphorylated
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Homo sapiens
input	[Complex:R-HSA-8854400] 2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SHC1 in the RET complex is phosphorylated
orthologousEvent	[BlackBoxEvent:R-DME-8854981] SHC1 in the RET complex is phosphorylated - Drosophila melanogaster [BlackBoxEvent:R-GGA-8854981] SHC1 in the RET complex is phosphorylated - Gallus gallus [BlackBoxEvent:R-XTR-8854981] SHC1 in the RET complex is phosphorylated - Xenopus tropicalis [BlackBoxEvent:R-DRE-8854981] SHC1 in the RET complex is phosphorylated - Danio rerio [BlackBoxEvent:R-SSC-8854981] SHC1 in the RET complex is phosphorylated - Sus scrofa [BlackBoxEvent:R-BTA-8854981] SHC1 in the RET complex is phosphorylated - Bos taurus [BlackBoxEvent:R-CFA-8854981] SHC1 in the RET complex is phosphorylated - Canis familiaris [BlackBoxEvent:R-RNO-8854981] SHC1 in the RET complex is phosphorylated - Rattus norvegicus [BlackBoxEvent:R-MMU-8854981] SHC1 in the RET complex is phosphorylated - Mus musculus
output	[Complex:R-HSA-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8854981
summation	[Summation:8854984] GDNF stimulation of neuronal cells induces the assembly of a...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
(hasEvent)	[Pathway:R-HSA-8853659] RET signaling