Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10

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2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8853732] Jupe, Steve, 2016-01-25
dbId	8853753
displayName	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
input	[Complex:R-HSA-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [DefinedSet:R-HSA-8854773] GRB7,GRB10 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8853787] The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 [LiteratureReference:8853772] Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
orthologousEvent	[Reaction:R-GGA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Gallus gallus [Reaction:R-DRE-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Danio rerio [Reaction:R-SSC-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Sus scrofa [Reaction:R-BTA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Bos taurus [Reaction:R-CFA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Canis familiaris [Reaction:R-RNO-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Rattus norvegicus [Reaction:R-MMU-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Mus musculus
output	[Complex:R-HSA-8854768] 2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8853792] RET tyrosine phosphorylation - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853753
summation	[Summation:8854375] Tyrosine-phosphorylated RET can bind GRB7 or GRB10 via tyros...

Referrals

(hasEvent)

[Pathway:R-HSA-8853659] RET signaling

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