Reactome | p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11

Schema > Reaction > Entries

p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 Show undefined attributes

authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8855517] Jupe, Steve, 2016-02-04
dbId	8855508
displayName	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
eventOf	[Pathway:R-HSA-8853659] RET signaling - Homo sapiens
input	[Complex:R-HSA-8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
orthologousEvent	[Reaction:R-GGA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Gallus gallus [Reaction:R-XTR-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Xenopus tropicalis [Reaction:R-SSC-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Sus scrofa [Reaction:R-BTA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Bos taurus [Reaction:R-CFA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Canis familiaris [Reaction:R-RNO-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Rattus norvegicus [Reaction:R-MMU-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Mus musculus
output	[Complex:R-HSA-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8855508
summation	[Summation:8855507] GDNF stimulation of neuronal cells induces the assembly of a...

Referrals

(hasEvent)

[Pathway:R-HSA-8853659] RET signaling