Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
mRNA Splicing - Major Pathway
Show undefined attributes
Go to Details
authored
[InstanceEdit:72076] Krainer, AR, 2003-06-05 08:30:23
[InstanceEdit:75078] Joshi-Tope, G, 2003-08-22 11:27:00
[InstanceEdit:9769907] May, Bruce, 2022-03-22
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:72076] Krainer, AR, 2003-06-05 08:30:23
dbId
72163
displayName
mRNA Splicing - Major Pathway
doi
10.3180/R-HSA-72163.3
edited
[InstanceEdit:9769907] May, Bruce, 2022-03-22
eventOf
[Pathway:R-HSA-72172] mRNA Splicing - Homo sapiens
followingEvent
[Pathway:R-HSA-72187] mRNA 3'-end processing - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:77621] mRNA splicing, via spliceosome
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-9770119] Formation of the Spliceosomal E complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770129] Formation of the Spliceosomal A complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770132] Formation of the Spliceosomal Pre-B complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770131] Formation of the Spliceosomal B* complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770141] Formation of the Spliceosomal C* complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation - Homo sapiens
[BlackBoxEvent:R-HSA-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Homo sapiens
[Reaction:R-HSA-9772351] Disassembly of the Intron Lariat Spliceosome (new) - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9709004] Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation
[LiteratureReference:9773071] How Is Precursor Messenger RNA Spliced by the Spliceosome?
[LiteratureReference:9773068] RNA Splicing by the Spliceosome
[LiteratureReference:9773072] A Day in the Life of the Exon Junction Complex
[LiteratureReference:9773074] Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome
[LiteratureReference:9773073] Spliceosome structure and function
[LiteratureReference:9773231] Intron-exon structures of eukaryotic model organisms
[LiteratureReference:9771902] A compensatory base change in U1 snRNA suppresses a 5' splice site mutation
[LiteratureReference:9770231] Association of U2 snRNP with the spliceosomal complex E
[LiteratureReference:9770219] Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
[LiteratureReference:72109] Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:8865895] Dynamic protein-protein interaction wiring of the human spliceosome
[LiteratureReference:8850757] Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
[LiteratureReference:8865896] Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
[LiteratureReference:9771897] Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition
[LiteratureReference:9771907] Noncanonical registers and base pairs in human 5' splice-site selection
[LiteratureReference:9771890] Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing
[LiteratureReference:9771893] U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
[LiteratureReference:5420912] Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex
[LiteratureReference:9770232] Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
[LiteratureReference:5566497] Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes
[LiteratureReference:9771903] Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
[LiteratureReference:9770261] Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways
[LiteratureReference:9771887] Molecular architecture of the human 17S U2 snRNP
[LiteratureReference:9771906] Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles
[LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
[LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
[LiteratureReference:9772622] Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
[LiteratureReference:9769529] Structures of the human pre-catalytic spliceosome and its precursor spliceosome
[LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:9769520] Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
[LiteratureReference:9772614] The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site
[LiteratureReference:5566502] Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
[LiteratureReference:8865916] Isolation of an active step I spliceosome and composition of its RNP core
[LiteratureReference:9772724] Exon, intron and splice site locations in the spliceosomal B complex
[LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
[LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
[LiteratureReference:9772624] Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
[LiteratureReference:9769580] Structure of the human activated spliceosome in three conformational states
[LiteratureReference:6806782] Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein
[LiteratureReference:9772623] The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
[LiteratureReference:5420900] Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
[LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method
[LiteratureReference:9769577] Structure and Conformational Dynamics of the Human Spliceosomal B
act
Complex
[LiteratureReference:9770585] Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
[LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
[LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
[LiteratureReference:8850870] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
[LiteratureReference:9772093] Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
[LiteratureReference:9772088] Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
[LiteratureReference:8865939] CWC22 connects pre-mRNA splicing and exon junction complex assembly
[LiteratureReference:9772613] Structure of a human catalytic step I spliceosome
[LiteratureReference:9772742] The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis
[LiteratureReference:9772746] Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing
[LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation
[LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome
[LiteratureReference:8984694] The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
[LiteratureReference:9769585] A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
[LiteratureReference:9769600] Structures of the human spliceosomes before and after release of the ligated exon
[LiteratureReference:9772736] A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
[LiteratureReference:9770592] Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment
[LiteratureReference:5566492] Isolation and characterization of post-splicing lariat-intron complexes
[LiteratureReference:9772987] Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion
[LiteratureReference:9771082] Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release
[LiteratureReference:9772984] TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly
[LiteratureReference:9772981] Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway
[LiteratureReference:9772985] Structural basis for DEAH-helicase activation by G-patch proteins
modified
[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name
mRNA Splicing - Major Pathway
pre-mRNA splicing
U2 Dependent Splicing
orthologousEvent
[Pathway:R-DDI-72163] mRNA Splicing - Major Pathway - Dictyostelium discoideum
[Pathway:R-CEL-72163] mRNA Splicing - Major Pathway - Caenorhabditis elegans
[Pathway:R-DME-72163] mRNA Splicing - Major Pathway - Drosophila melanogaster
[Pathway:R-DRE-72163] mRNA Splicing - Major Pathway - Danio rerio
[Pathway:R-SSC-72163] mRNA Splicing - Major Pathway - Sus scrofa
[Pathway:R-BTA-72163] mRNA Splicing - Major Pathway - Bos taurus
[Pathway:R-CFA-72163] mRNA Splicing - Major Pathway - Canis familiaris
[Pathway:R-RNO-72163] mRNA Splicing - Major Pathway - Rattus norvegicus
[Pathway:R-MMU-72163] mRNA Splicing - Major Pathway - Mus musculus
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Clément, 2022-10-20
revised
[InstanceEdit:9769907] May, Bruce, 2022-03-22
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-72163
summation
[Summation:9773064] Eukaryotic genes are transcribed to yield pre-mRNAs that are...
Referrals
(precedingEvent)
[Pathway:R-HSA-72187] mRNA 3'-end processing
(hasEvent)
[Pathway:R-HSA-72172] mRNA Splicing
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text