Reactome | Formation of the Spliceosomal B* complex

Schema > BlackBoxEvent > Entries

Formation of the Spliceosomal B* complex Show undefined attributes

authored	[InstanceEdit:9769907] May, Bruce, 2022-03-22
catalystActivity	[CatalystActivity:9770423] RNA helicase activity of Spliceosomal Bact complex [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770146] May, Bruce, 2022-03-24
dbId	9770131
deleted	[Deleted:9830326] Deletion of instance: 156661
displayName	Formation of the Spliceosomal B* complex
edited	[InstanceEdit:9769907] May, Bruce, 2022-03-22
eventOf	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849148] CASC3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867898] CWC25 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770427] DHX35 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770419] GPATCH1 [nucleoplasm] [Complex:R-HSA-156657] Magoh-Y14 complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770428] NSRP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769592] PPIG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8952113] PPIL4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867893] PPWD1 [nucleoplasm] [Complex:R-HSA-9769560] Spliceosomal Bact complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867884] SYF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156776] UPF3B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770425] WDR70 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770430] YJU2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome. [LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly [LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis [LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count [LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method [LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex [LiteratureReference:9772088] Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly [LiteratureReference:8865939] CWC22 connects pre-mRNA splicing and exon junction complex assembly [LiteratureReference:9772093] Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay [LiteratureReference:9772613] Structure of a human catalytic step I spliceosome [LiteratureReference:9770585] Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes [LiteratureReference:8850870] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Formation of the Spliceosomal B* complex
orthologousEvent	[BlackBoxEvent:R-MMU-9770131] Formation of the Spliceosomal B* complex - Mus musculus [BlackBoxEvent:R-RNO-9770131] Formation of the Spliceosomal B* complex - Rattus norvegicus [BlackBoxEvent:R-DME-9770131] Formation of the Spliceosomal B* complex - Drosophila melanogaster
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867885] CWC27 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8850837] DHX16 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8850839] GPKOW [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2396419] MFAP1 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-9769523] RES complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769563] RNF113A [nucleoplasm] [Complex:R-HSA-71967] SF3A [nucleoplasm] [Complex:R-HSA-71976] SF3B [nucleoplasm] [Complex:R-HSA-9794539] Spliceosomal B* complex [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9770131
summation	[Summation:9771078] DHX16 (homolog of yeast Prp2) hydrolyzes ATP in the Spliceos...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat
(hasEvent)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(replacementInstances)	[Deleted:9830326] Deletion of instance: 156661

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