Reactome | mRNA Splicing

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mRNA Splicing - Major Pathway Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101903
displayName	mRNA Splicing - Major Pathway
eventOf	[Pathway:R-MMU-72172] mRNA Splicing - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-72187] mRNA 3'-end processing - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:77621] mRNA splicing, via spliceosome
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-MMU-9770119] Formation of the Spliceosomal E complex - Mus musculus [BlackBoxEvent:R-MMU-9770142] Formation of the Spliceosomal B complex - Mus musculus [BlackBoxEvent:R-MMU-9770145] Formation of the Spliceosomal Bact complex - Mus musculus [BlackBoxEvent:R-MMU-9770131] Formation of the Spliceosomal B* complex - Mus musculus [BlackBoxEvent:R-MMU-9794542] Formation of the Spliceosomal C complex containing intron lariat - Mus musculus [BlackBoxEvent:R-MMU-9770141] Formation of the Spliceosomal C* complex - Mus musculus [BlackBoxEvent:R-MMU-9770236] Formation of the Spliceosomal P complex and exon ligation - Mus musculus [BlackBoxEvent:R-MMU-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Mus musculus
inferredFrom	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	mRNA Splicing - Major Pathway pre-mRNA splicing U2 Dependent Splicing
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-72163
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-72172] mRNA Splicing
(precedingEvent)	[Pathway:R-MMU-72187] mRNA 3'-end processing
(inferredTo)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway