Reactome | Formation of the Spliceosomal C* complex

Schema > BlackBoxEvent > Entries

Formation of the Spliceosomal C* complex Show undefined attributes

authored	[InstanceEdit:9769907] May, Bruce, 2022-03-22
catalystActivity	[CatalystActivity:9770421] RNA helicase activity of Spliceosomal C complex [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643243] ATPase activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770146] May, Bruce, 2022-03-24
dbId	9770141
deleted	[Deleted:9830332] Deletion of instance: 72139
displayName	Formation of the Spliceosomal C* complex
edited	[InstanceEdit:9769907] May, Bruce, 2022-03-22
eventOf	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769591] CACTIN [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769601] DDX41 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5688092] DHX8 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769598] FAM32A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769599] FAM50A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72073] hSLU7 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769594] PRKRIP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5688093] PRPF18 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769593] SDE2 [nucleoplasm] [Complex:R-HSA-9770138] Spliceosomal C complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769596] STEEP1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome. [LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome [LiteratureReference:9770792] Cryo-EM structure of a human spliceosome activated for step 2 of splicing [LiteratureReference:9772739] Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity [LiteratureReference:9772746] Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing [LiteratureReference:9772742] The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis [LiteratureReference:9772729] A missense mutation in the splicing factor gene DHX38 is associated with early-onset retinitis pigmentosa with macular coloboma
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Formation of the Spliceosomal C* complex Formation of the Active Spliceosomal C complex (update)
orthologousEvent	[BlackBoxEvent:R-MMU-9770141] Formation of the Spliceosomal C* complex - Mus musculus [BlackBoxEvent:R-RNO-9770141] Formation of the Spliceosomal C* complex - Rattus norvegicus [BlackBoxEvent:R-CFA-9770141] Formation of the Spliceosomal C* complex - Canis familiaris [BlackBoxEvent:R-BTA-9770141] Formation of the Spliceosomal C* complex - Bos taurus [BlackBoxEvent:R-SSC-9770141] Formation of the Spliceosomal C* complex - Sus scrofa [BlackBoxEvent:R-DME-9770141] Formation of the Spliceosomal C* complex - Drosophila melanogaster [BlackBoxEvent:R-CEL-9770141] Formation of the Spliceosomal C* complex - Caenorhabditis elegans
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867898] CWC25 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770427] DHX35 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770419] GPATCH1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770428] NSRP1 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-9770118] Spliceosomal C* complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770425] WDR70 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770430] YJU2 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9770141
summation	[Summation:9771901] DHX38 (homolog of yeast Prp16) hydrolyzes ATP to remodel the...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation
(hasEvent)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(replacementInstances)	[Deleted:9830332] Deletion of instance: 72139

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