Reactome | Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)

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Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) Show undefined attributes

authored	[InstanceEdit:9770798] May, Bruce, 2022-04-14
catalystActivity	[CatalystActivity:9770416] ATP-dependent activity, acting on RNA of Spliceosomal P complex [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770848] May, Bruce, 2022-04-15
dbId	9770847
displayName	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
edited	[InstanceEdit:9770798] May, Bruce, 2022-04-14
eventOf	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-9772351] Disassembly of the Intron Lariat Spliceosome (new) - Homo sapiens [Reaction:R-HSA-77607] Formation of stem-loop structure in ApoB mRNA - Homo sapiens [Reaction:R-HSA-8849157] TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770846] CWF19L2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5688097] DHX15 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8869311] GCFC2 [nucleoplasm] [Complex:R-HSA-9769587] Spliceosomal P complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8869310] TFIP11 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5566492] Isolation and characterization of post-splicing lariat-intron complexes [LiteratureReference:9769600] Structures of the human spliceosomes before and after release of the ligated exon [LiteratureReference:9771082] Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release [LiteratureReference:9770592] Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment [LiteratureReference:9772736] A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome [LiteratureReference:9772987] Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
orthologousEvent	[BlackBoxEvent:R-MMU-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Mus musculus [BlackBoxEvent:R-RNO-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Rattus norvegicus [BlackBoxEvent:R-BTA-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Bos taurus [BlackBoxEvent:R-SSC-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Sus scrofa
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769588] C9orf78 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769591] CACTIN [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769561] CCDC12 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865956] CWC22 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769601] DDX41 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3900136] DDX5 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5688092] DHX8 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769598] FAM32A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769599] FAM50A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72073] hSLU7 [nucleoplasm] [Complex:R-HSA-9770234] Intron Lariat Spliceosome (ILS) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769590] LENG1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769602] NKAP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769592] PPIG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8952110] PPIL3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867893] PPWD1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769594] PRKRIP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769593] SDE2 [nucleoplasm] [Complex:R-HSA-9770431] spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865888] SRRM2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6814858] SRRT [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769596] STEEP1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9770847
summation	[Summation:9771079] DHX8 (homolog of yeast Prp22) hydrolyzes ATP and translocate...

Referrals

(precedingEvent)	[Reaction:R-HSA-9772351] Disassembly of the Intron Lariat Spliceosome (new) [Reaction:R-HSA-77607] Formation of stem-loop structure in ApoB mRNA [Reaction:R-HSA-8849157] TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally
(hasEvent)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway

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