Reactome | Formation of the Spliceosomal C complex containing intron lariat

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Formation of the Spliceosomal C complex containing intron lariat Show undefined attributes

authored	[InstanceEdit:9794536] May, Bruce, 2022-07-13
catalystActivity	[CatalystActivity:9794535] first spliceosomal transesterification activity of Spliceosomal B* complex [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9794540] May, Bruce, 2022-07-13
dbId	9794542
deleted	[Deleted:9830330] Deletion of instance: 72143 [Deleted:9830331] Deletion of instance: 72130
displayName	Formation of the Spliceosomal C complex containing intron lariat
edited	[InstanceEdit:9794536] May, Bruce, 2022-07-13
eventOf	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9770141] Formation of the Spliceosomal C* complex - Homo sapiens
input	[Complex:R-HSA-9794539] Spliceosomal B* complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome. [LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly [LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis [LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count [LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method [LiteratureReference:9772613] Structure of a human catalytic step I spliceosome
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of the Spliceosomal C complex containing intron lariat First catalytic step of mRNA splicing
orthologousEvent	[BlackBoxEvent:R-PFA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Plasmodium falciparum [BlackBoxEvent:R-SPO-9794542] Formation of the Spliceosomal C complex containing intron lariat - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-9794542] Formation of the Spliceosomal C complex containing intron lariat - Dictyostelium discoideum [BlackBoxEvent:R-CEL-9794542] Formation of the Spliceosomal C complex containing intron lariat - Caenorhabditis elegans [BlackBoxEvent:R-DME-9794542] Formation of the Spliceosomal C complex containing intron lariat - Drosophila melanogaster [BlackBoxEvent:R-GGA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Gallus gallus [BlackBoxEvent:R-XTR-9794542] Formation of the Spliceosomal C complex containing intron lariat - Xenopus tropicalis [BlackBoxEvent:R-DRE-9794542] Formation of the Spliceosomal C complex containing intron lariat - Danio rerio [BlackBoxEvent:R-SSC-9794542] Formation of the Spliceosomal C complex containing intron lariat - Sus scrofa [BlackBoxEvent:R-BTA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Bos taurus [BlackBoxEvent:R-CFA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Canis familiaris [BlackBoxEvent:R-RNO-9794542] Formation of the Spliceosomal C complex containing intron lariat - Rattus norvegicus [BlackBoxEvent:R-MMU-9794542] Formation of the Spliceosomal C complex containing intron lariat - Mus musculus
output	[Complex:R-HSA-9770138] Spliceosomal C complex [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9770131] Formation of the Spliceosomal B* complex - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9794542
summation	[Summation:9794537] The Spliceosomal B* complex and Spliceosomal C complex diffe...

Referrals

(replacementInstances)	[Deleted:9830330] Deletion of instance: 72143 [Deleted:9830331] Deletion of instance: 72130
(hasEvent)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(precedingEvent)	[BlackBoxEvent:R-HSA-9770141] Formation of the Spliceosomal C* complex

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