Reactome | Formation of the Spliceosomal Pre-B complex

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Formation of the Spliceosomal Pre-B complex Show undefined attributes

authored	[InstanceEdit:9769907] May, Bruce, 2022-03-22
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770146] May, Bruce, 2022-03-24
dbId	9770132
displayName	Formation of the Spliceosomal Pre-B complex
edited	[InstanceEdit:9769907] May, Bruce, 2022-03-22
eventOf	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-156649] ALYREF [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849139] DDX39B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770239] IK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769525] PRPF4B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6791189] SKIV2L2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770259] SMU1 [nucleoplasm] [Complex:R-HSA-9970412] Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156781] SRRM1 [nucleoplasm] [Complex:R-HSA-77506] U4:U5:U6 tri-snRNP complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity [LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation [LiteratureReference:9769529] Structures of the human pre-catalytic spliceosome and its precursor spliceosome [LiteratureReference:9769520] Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA [LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex [LiteratureReference:9771906] Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles [LiteratureReference:9818098] Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site
maxDepth	1
modified	[InstanceEdit:9971062] Orlic-Milacic, Marija, 2025-11-04
name	Formation of the Spliceosomal Pre-B complex
output	[EntityWithAccessionedSequence:R-HSA-72048] CCAR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-53703] DNAJC8 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770246] HTATSF1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770253] PPP1R8 [nucleoplasm] [Complex:R-HSA-9769528] Spliceosomal Pre-B complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72043] SUGP1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9770129] Formation of the Spliceosomal A complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9770132
summation	[Summation:9770263] The U4/U6.U5 tri-snRNP complex loosely binds the Spliceosoma...
updateTrackers	[UpdateTracker:9971887] Update Tracker - [BlackBoxEvent:9770132] Formation of the Spliceosomal Pre-B complex - v95:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9971887] Update Tracker - [BlackBoxEvent:9770132] Formation of the Spliceosomal Pre-B complex - v95:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(precedingEvent)	[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex

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