Reactome | Lysine catabolism

Schema > Pathway > Entries

Lysine catabolism Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
dbId	71064
deleted	[Deleted:9640342] Deletion of instance: 6788656
displayName	Lysine catabolism
doi	10.3180/REACT_1298.1
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10836] obsolete lysine catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Homo sapiens [Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Homo sapiens [Reaction:R-HSA-5693347] CRYM reduces P2C to PPCA - Homo sapiens [Reaction:R-HSA-6783880] PIPOX oxidises PPCA to P6C - Homo sapiens [Reaction:R-HSA-6783883] P6C transforms to 2AMAS - Homo sapiens [BlackBoxEvent:R-HSA-9960428] 2AMAS transport from peroxisome to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-6788611] HYKK phosphorylates 5HLYS - Homo sapiens [Reaction:R-HSA-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL - Homo sapiens [Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Homo sapiens [Reaction:R-HSA-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Homo sapiens [Reaction:R-HSA-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Homo sapiens [Reaction:R-HSA-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Homo sapiens [Pathway:R-HSA-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA - Homo sapiens [Reaction:R-HSA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[Book:70939] The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR Errors of lysine metabolism 0079130356 [Book:71041] The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and glutaric acidemia 0079130356 [LiteratureReference:70926] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities [LiteratureReference:70944] Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Lysine catabolism
orthologousEvent	[Pathway:R-MMU-71064] Lysine catabolism - Mus musculus [Pathway:R-CFA-71064] Lysine catabolism - Canis familiaris [Pathway:R-BTA-71064] Lysine catabolism - Bos taurus [Pathway:R-SSC-71064] Lysine catabolism - Sus scrofa [Pathway:R-DRE-71064] Lysine catabolism - Danio rerio [Pathway:R-XTR-71064] Lysine catabolism - Xenopus tropicalis [Pathway:R-GGA-71064] Lysine catabolism - Gallus gallus [Pathway:R-DME-71064] Lysine catabolism - Drosophila melanogaster [Pathway:R-CEL-71064] Lysine catabolism - Caenorhabditis elegans [Pathway:R-DDI-71064] Lysine catabolism - Dictyostelium discoideum [Pathway:R-SPO-71064] Lysine catabolism - Schizosaccharomyces pombe [Pathway:R-SCE-71064] Lysine catabolism - Saccharomyces cerevisiae [Pathway:R-RNO-71064] Lysine catabolism - Rattus norvegicus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2003-05-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9907756] D'Eustachio, Peter, 2024-04-17 [InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
revised	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-71064
summation	[Summation:71065] In humans, most catabolism of L-lysine normally proceeds via...
updateTrackers	[UpdateTracker:9788792] Update Tracker - [Pathway:71064] Lysine catabolism - v40:[updateContainedRLE] [UpdateTracker:9911104] Update Tracker - [Pathway:71064] Lysine catabolism - v89:[add_removeHasEvent] [UpdateTracker:9790861] Update Tracker - [Pathway:71064] Lysine catabolism - v32:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9790173] Update Tracker - [Pathway:71064] Lysine catabolism - v35:[updateContainedRLE] [UpdateTracker:9964742] Update Tracker - [Pathway:71064] Lysine catabolism - v94:[removeHasEvent] [UpdateTracker:9777696] Update Tracker - [Pathway:71064] Lysine catabolism - v69:[updateContainedRLE] [UpdateTracker:9791722] Update Tracker - [Pathway:71064] Lysine catabolism - v26:[addHasEvent] [UpdateTracker:9784395] Update Tracker - [Pathway:71064] Lysine catabolism - v54:[addHasEvent] [UpdateTracker:9783810] Update Tracker - [Pathway:71064] Lysine catabolism - v55:[addHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives
(hasEncapsulatedEvent)	[Pathway:R-HSA-9857492] Protein lipoylation
(replacementInstances)	[Deleted:9640342] Deletion of instance: 6788656
(updatedInstance)	[UpdateTracker:9788792] Update Tracker - [Pathway:71064] Lysine catabolism - v40:[updateContainedRLE] [UpdateTracker:9911104] Update Tracker - [Pathway:71064] Lysine catabolism - v89:[add_removeHasEvent] [UpdateTracker:9790861] Update Tracker - [Pathway:71064] Lysine catabolism - v32:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9790173] Update Tracker - [Pathway:71064] Lysine catabolism - v35:[updateContainedRLE] [UpdateTracker:9964742] Update Tracker - [Pathway:71064] Lysine catabolism - v94:[removeHasEvent] [UpdateTracker:9777696] Update Tracker - [Pathway:71064] Lysine catabolism - v69:[updateContainedRLE] [UpdateTracker:9791722] Update Tracker - [Pathway:71064] Lysine catabolism - v26:[addHasEvent] [UpdateTracker:9784395] Update Tracker - [Pathway:71064] Lysine catabolism - v54:[addHasEvent] [UpdateTracker:9783810] Update Tracker - [Pathway:71064] Lysine catabolism - v55:[addHasEvent]

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