Reactome | alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate

Schema > Reaction > Entries

alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70950] 2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643448] 2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix] Crystal structure of human kynurenine aminotransferase II
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667571] RHEA:12602 [DatabaseIdentifier:9929212] RHEA:12602
dbId	70952
displayName	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA - Homo sapiens
input	[SimpleEntity:R-ALL-508531] 2AMA [mitochondrial matrix] [SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70944] Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) [LiteratureReference:508552] Crystal structure of human kynurenine aminotransferase II [LiteratureReference:508560] Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate 2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate
negativePrecedingEvent	[NegativePrecedingEvent:9908860] Futile Cycle: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
orthologousEvent	[Reaction:R-SCE-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Saccharomyces cerevisiae [Reaction:R-SPO-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Schizosaccharomyces pombe [Reaction:R-DDI-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Dictyostelium discoideum [Reaction:R-GGA-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Gallus gallus [Reaction:R-XTR-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Xenopus tropicalis [Reaction:R-SSC-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Sus scrofa [Reaction:R-BTA-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Bos taurus [Reaction:R-CFA-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Canis familiaris [Reaction:R-RNO-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Rattus norvegicus [Reaction:R-MMU-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Mus musculus
output	[SimpleEntity:R-ALL-70951] 2-OA [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70952
summation	[Summation:178458] Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catal...
updateTrackers	[UpdateTracker:9791064] Update Tracker - [Reaction:70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791064] Update Tracker - [Reaction:70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA [NegativePrecedingEvent:9908861] Futile Cycle: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate