Reactome | glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2

Schema > Reaction > Entries

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71044] glutaryl-CoA dehydrogenase activity of GCDH tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643968] glutaryl-CoA dehydrogenase activity of GCDH tetramer [mitochondrial matrix] Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH)
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667523] RHEA:30848 [DatabaseIdentifier:9929224] RHEA:30848
dbId	71046
displayName	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-70955] GL-CoA [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508551] Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions [LiteratureReference:508570] Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH)
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2
orthologousEvent	[Reaction:R-DDI-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Dictyostelium discoideum [Reaction:R-CEL-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Caenorhabditis elegans [Reaction:R-DME-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Drosophila melanogaster [Reaction:R-GGA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Gallus gallus [Reaction:R-XTR-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Xenopus tropicalis [Reaction:R-DRE-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Danio rerio [Reaction:R-SSC-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Sus scrofa [Reaction:R-BTA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Bos taurus [Reaction:R-CFA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Canis familiaris [Reaction:R-RNO-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Rattus norvegicus [Reaction:R-MMU-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Mus musculus
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-71045] crotonyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9858590] DLST transfers glutaryl to CoA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71046
summation	[Summation:178815] Mitochondrial glutaryl-CoA dehydrogenase (GCDH) catalyzes th...
updateTrackers	[UpdateTracker:9790944] Update Tracker - [Reaction:71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9939624] Update Tracker - [Reaction:71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - v92:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9790944] Update Tracker - [Reaction:71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9939624] Update Tracker - [Reaction:71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - v92:[removeInput]
(hasEvent)	[Pathway:R-HSA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-HSA-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA

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