Reactome | CRYM reduces P2C to PPCA

Schema > Reaction > Entries

CRYM reduces P2C to PPCA Show undefined attributes

authored	[InstanceEdit:5693366] Jassal, Bijay, 2015-05-15
catalystActivity	[CatalystActivity:5693316] delta1-piperideine-2-carboxylate reductase activity of CRYM [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:5693366] Jassal, Bijay, 2015-05-15
crossReference	[DatabaseIdentifier:12667575] RHEA:12526 [DatabaseIdentifier:9925989] RHEA:12526
dbId	5693347
displayName	CRYM reduces P2C to PPCA
edited	[InstanceEdit:5693366] Jassal, Bijay, 2015-05-15
eventOf	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-6783880] PIPOX oxidises PPCA to P6C - Homo sapiens
input	[SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix] [SimpleEntity:R-ALL-5693311] P2C [peroxisomal matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5693315] Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/?-Crystallin Under Physiological Conditions [LiteratureReference:5693358] Crystal structure of human micro-crystallin complexed with NADPH
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CRYM reduces P2C to PPCA Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)
orthologousEvent	[Reaction:R-SCE-5693347] CRYM reduces P2C to PPCA - Saccharomyces cerevisiae [Reaction:R-SPO-5693347] CRYM reduces P2C to PPCA - Schizosaccharomyces pombe [Reaction:R-DDI-5693347] CRYM reduces P2C to PPCA - Dictyostelium discoideum [Reaction:R-DME-5693347] CRYM reduces P2C to PPCA - Drosophila melanogaster [Reaction:R-GGA-5693347] CRYM reduces P2C to PPCA - Gallus gallus [Reaction:R-XTR-5693347] CRYM reduces P2C to PPCA - Xenopus tropicalis [Reaction:R-DRE-5693347] CRYM reduces P2C to PPCA - Danio rerio [Reaction:R-SSC-5693347] CRYM reduces P2C to PPCA - Sus scrofa [Reaction:R-BTA-5693347] CRYM reduces P2C to PPCA - Bos taurus [Reaction:R-CFA-5693347] CRYM reduces P2C to PPCA - Canis familiaris [Reaction:R-RNO-5693347] CRYM reduces P2C to PPCA - Rattus norvegicus [Reaction:R-MMU-5693347] CRYM reduces P2C to PPCA - Mus musculus
output	[SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix] [SimpleEntity:R-ALL-5693325] PPCA [peroxisomal matrix]
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693347
summation	[Summation:5693340] The ketimine reductase mu-crystallin protein (CRYM) is a key...

Referrals

(hasEvent)	[Pathway:R-HSA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-HSA-6783880] PIPOX oxidises PPCA to P6C