Reactome | lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

Schema > Reaction > Entries

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70934] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of AASS tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643643] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of AASS tetramer [mitochondrial matrix] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:11880992] Rhea:19375
dbId	70938
displayName	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29444] L-Lys [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70926] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities [LiteratureReference:70929] Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
orthologousEvent	[Reaction:R-BTA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Bos taurus [Reaction:R-SCE-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Saccharomyces cerevisiae [Reaction:R-SPO-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Schizosaccharomyces pombe [Reaction:R-DDI-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Dictyostelium discoideum [Reaction:R-CEL-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Caenorhabditis elegans [Reaction:R-DME-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Drosophila melanogaster [Reaction:R-GGA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Gallus gallus [Reaction:R-XTR-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Xenopus tropicalis [Reaction:R-DRE-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Danio rerio [Reaction:R-SSC-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Sus scrofa [Reaction:R-CFA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Canis familiaris [Reaction:R-RNO-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Rattus norvegicus [Reaction:R-MMU-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Mus musculus
output	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] [SimpleEntity:R-ALL-30176] SACN [mitochondrial matrix]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70938
summation	[Summation:178935] The saccharopine dehydrogenase activity of lysine-ketoglutar...

Referrals

(hasEvent)	[Pathway:R-HSA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

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