Reactome | Lysine catabolism

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Lysine catabolism Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555703
displayName	Lysine catabolism
eventOf	[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10836] obsolete lysine catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Sus scrofa [Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Sus scrofa [Reaction:R-SSC-5693347] CRYM reduces P2C to PPCA - Sus scrofa [Reaction:R-SSC-6783880] PIPOX oxidises PPCA to P6C - Sus scrofa [Reaction:R-SSC-6788611] HYKK phosphorylates 5HLYS - Sus scrofa [Reaction:R-SSC-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL - Sus scrofa [Reaction:R-SSC-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Sus scrofa [Reaction:R-SSC-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Sus scrofa [Reaction:R-SSC-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Sus scrofa [Reaction:R-SSC-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Sus scrofa [Pathway:R-SSC-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA - Sus scrofa [Reaction:R-SSC-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Sus scrofa
inferredFrom	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Lysine catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-71064
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives
(hasEncapsulatedEvent)	[Pathway:R-SSC-9857492] Protein lipoylation
(inferredTo)	[Pathway:R-HSA-71064] Lysine catabolism

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