Reactome | Phosphorylation of MDM4 by ATM

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Phosphorylation of MDM4 by ATM Show undefined attributes

authored	[InstanceEdit:264438] Matthews, L, 2008-03-31 10:45:58
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21
dbId	349455
displayName	Phosphorylation of MDM4 by ATM
edited	[InstanceEdit:351820] Matthews, L, 2008-05-12 14:39:01
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-6804932] p-S166,S188-MDM2:MDM4 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:349458] Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage [LiteratureReference:349453] ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of MDM4 by ATM
negativePrecedingEvent	[NegativePrecedingEvent:9766476] Futile Cycle: MDM2 ubiquitinates TP53
orthologousEvent	[Reaction:R-GGA-349455] Phosphorylation of MDM4 by ATM - Gallus gallus [Reaction:R-DRE-349455] Phosphorylation of MDM4 by ATM - Danio rerio [Reaction:R-CFA-349455] Phosphorylation of MDM4 by ATM - Canis familiaris [Reaction:R-RNO-349455] Phosphorylation of MDM4 by ATM - Rattus norvegicus [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-6804939] p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-349455
summation	[Summation:349432] Human MDM4 (MDMX) is phosphorylated on serine residue S403 b...

Referrals

(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53 [Pathway:R-HSA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2