MDM2 forms homo- or heterodimers

Stable Identifier
Reaction [transition]
Homo sapiens
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To efficiently function as an E3 ubiquitin ligase, MDM2 has to form dimers or higher order oligomers. MDM2 can homodimerize (Cheng et al. 2011) or heterodimerize with MDM4 (MDMX) (Sharp et al. 1999, Huang et al. 2011, Pant et al. 2011). Dimerization involves the RING domain of MDM2 and/or MDM4. Heterodimers of MDM2 and MDM4 may be particularly important during embryonic development (Pant et al. 2011).

Literature References
PubMed ID Title Journal Year
21986495 Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

Chen, L, Chen, J, Cheng, Q, Li, B, Cross, B, Li, Z

Mol. Cell. Biol. 2011
21730132 Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

Pant, V, Quintás-Cardama, A, Iwakuma, T, Lozano, G, Xiong, S

Proc. Natl. Acad. Sci. U.S.A. 2011
21730163 The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

Ganapathy, S, Wang, ZG, Liao, X, Yang, J, Li, Y, Yuan, ZM, Shadfan, M, Kawai, H, Zuo, Y, Huang, L, Yan, Z

Proc. Natl. Acad. Sci. U.S.A. 2011
10608892 Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Kratowicz, SA, Sank, MJ, George, DL, Sharp, DA

J. Biol. Chem. 1999
This event is regulated
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