Reactome | MDM2 binds TP53

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MDM2 binds TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5633454] Orlic-Milacic, Marija, 2014-10-31
dbId	5633460
displayName	MDM2 binds TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-6804998] p14ARF forms a ternary complex with MDM2 and TP53 - Homo sapiens [Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53 - Homo sapiens
input	[DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5633458] The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation [LiteratureReference:5633467] Amplification of a gene encoding a p53-associated protein in human sarcomas [LiteratureReference:5633461] Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 [LiteratureReference:5633453] Mapping of the p53 and mdm-2 interaction domains [LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:6804878] HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
modified	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
name	MDM2 binds TP53
negativePrecedingEvent	[NegativePrecedingEvent:9766479] Futile Cycle: MDM2 ubiquitinates TP53
orthologousEvent	[Reaction:R-DRE-5633460] MDM2 binds TP53 - Danio rerio [Reaction:R-CFA-5633460] MDM2 binds TP53 - Canis familiaris [Reaction:R-RNO-5633460] MDM2 binds TP53 - Rattus norvegicus [Reaction:R-MMU-5633460] MDM2 binds TP53 - Mus musculus
output	[Complex:R-HSA-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens [Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8979263] Negative regulation by 'PHF20 [nucleoplasm]'
regulationReference	[RegulationReference:9641991] Negative regulation by 'PHF20 [nucleoplasm]' PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5633460
summation	[Summation:5633465] The N-terminal portion of MDM2 binds the N-terminal transact...

Referrals

(hasEvent)	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation [Pathway:R-HSA-69541] Stabilization of p53
(precedingEvent)	[Reaction:R-HSA-6804998] p14ARF forms a ternary complex with MDM2 and TP53 [Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53

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