Reactome | p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

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p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:6798364] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-6804995] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5633460] MDM2 binds TP53 - Homo sapiens
created	[InstanceEdit:6804733] Orlic-Milacic, Marija, 2015-10-14
dbId	6804745
displayName	p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
hasMember	[Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Homo sapiens [Complex:R-HSA-6804932] p-S166,S188-MDM2:MDM4 [nucleoplasm] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Mus musculus [DefinedSet:R-RNO-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Rattus norvegicus [DefinedSet:R-CFA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Canis familiaris [Complex:R-BTA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Bos taurus [Complex:R-SSC-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Sus scrofa [DefinedSet:R-DRE-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Danio rerio [Complex:R-XTR-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Xenopus tropicalis [DefinedSet:R-GGA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Gallus gallus
literatureReference	[LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:6804738] Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability [LiteratureReference:6804740] The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
maxDepth	3
modified	[InstanceEdit:8932867] Orlic-Milacic, Marija, 2016-07-29
name	p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4
producedByEvent	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens [Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-6804745
updateTrackers	[UpdateTracker:9894780] Update Tracker - [DefinedSet:6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - v58:[add_removeHasMember, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9894780] Update Tracker - [DefinedSet:6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - v58:[add_removeHasMember, modifyName]
(physicalEntity)	[CatalystActivity:6798364] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
(output)	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers [Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53
(input)	[Reaction:R-HSA-5633460] MDM2 binds TP53
(hasComponent)	[Complex:R-HSA-6804995] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] [Complex:R-HSA-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]

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