Reactome | MDM2 homodimers auto-ubiquitinate

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MDM2 homodimers auto-ubiquitinate Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6804934] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6804930] Orlic-Milacic, Marija, 2015-10-15
dbId	6804942
displayName	MDM2 homodimers auto-ubiquitinate
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7 - Homo sapiens
input	[Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] 2 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3215306] Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 [LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MDM2 homodimers auto-ubiquitinate
orthologousEvent	[Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate - Xenopus tropicalis [Reaction:R-GGA-6804942] MDM2 homodimers auto-ubiquitinate - Gallus gallus [Reaction:R-DRE-6804942] MDM2 homodimers auto-ubiquitinate - Danio rerio [Reaction:R-SSC-6804942] MDM2 homodimers auto-ubiquitinate - Sus scrofa [Reaction:R-BTA-6804942] MDM2 homodimers auto-ubiquitinate - Bos taurus [Reaction:R-CFA-6804942] MDM2 homodimers auto-ubiquitinate - Canis familiaris [Reaction:R-RNO-6804942] MDM2 homodimers auto-ubiquitinate - Rattus norvegicus [Reaction:R-MMU-6804942] MDM2 homodimers auto-ubiquitinate - Mus musculus
output	[Complex:R-HSA-6804935] PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6804942
summation	[Summation:6804950] MDM2 undergoes auto-ubiquitination (Fang et al. 2000). Forma...

Referrals

(hasEvent)	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7

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