Reactome | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

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TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6803212] Orlic-Milacic, Marija, 2015-10-05
crossReference	[DatabaseIdentifier:12819521] BioModels Database:BIOMD0000000287 [DatabaseIdentifier:12819591] BioModels Database:BIOMD0000000188 [DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819593] BioModels Database:BIOMD0000000634
dbId	6803204
displayName	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter - Homo sapiens [BlackBoxEvent:R-HSA-3700984] TP53 family members stimulate BAX transcription - Homo sapiens [Reaction:R-HSA-4331331] TP53 binds the PMAIP1 (NOXA) promoter - Homo sapiens [BlackBoxEvent:R-HSA-140214] TP53 stimulates PMAIP1 (NOXA) expression - Homo sapiens [Reaction:R-HSA-4331340] TP53 binds the BBC3 (PUMA) promoter - Homo sapiens [BlackBoxEvent:R-HSA-139913] TP53 stimulates BBC3 (PUMA) expression - Homo sapiens [Reaction:R-HSA-6791285] TP53 binds the BID gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-6791291] TP53 stimulates BID gene expression - Homo sapiens [Reaction:R-HSA-6797993] TP53 and CREBBP bind BNIP3L gene - Homo sapiens [BlackBoxEvent:R-HSA-6798004] TP53 stimulates BNIP3L expression - Homo sapiens [Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6798611] TP53 stimulates and ZNF420 inhibits TP53AIP1 expression - Homo sapiens [Reaction:R-HSA-6798624] ZNF420 binds TP53AIP1 gene - Homo sapiens [Reaction:R-HSA-6799097] ATM phosphorylates ZNF420 - Homo sapiens [Reaction:R-HSA-6801166] TP53 binds the STEAP3 gene - Homo sapiens [BlackBoxEvent:R-HSA-6801184] TP53 stimulates STEAP3 expression - Homo sapiens [Reaction:R-HSA-6801195] STEAP3 binds BNIP3L - Homo sapiens [Reaction:R-HSA-6801209] TP53 binds the TRIAP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6801213] TP53 stimulates TRIAP1 expression - Homo sapiens [Reaction:R-HSA-6801242] TRIAP1 binds PRELID1, PRELID3A - Homo sapiens [Reaction:R-HSA-6801250] TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane - Homo sapiens [Reaction:R-HSA-6791302] TP53 binds the AIFM2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-6791306] TP53 stimulates AIFM2 gene expression - Homo sapiens [Reaction:R-HSA-6799418] TP53 binds the TP53INP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6799416] TP53 stimulates expression of TP53INP1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-06-27
literatureReference	[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members [LiteratureReference:140442] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53 [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis [LiteratureReference:6799802] ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo [LiteratureReference:6800007] iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:6799790] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax [LiteratureReference:6791288] BID regulation by p53 contributes to chemosensitivity [LiteratureReference:6798000] Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth [LiteratureReference:6801169] The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase [LiteratureReference:6801207] p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway [LiteratureReference:6791300] AMID is a p53-inducible gene downregulated in tumors [LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis [LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
orthologousEvent	[Pathway:R-PFA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Plasmodium falciparum [Pathway:R-SCE-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Saccharomyces cerevisiae [Pathway:R-SPO-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Schizosaccharomyces pombe [Pathway:R-DDI-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Dictyostelium discoideum [Pathway:R-DME-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Drosophila melanogaster [Pathway:R-MMU-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Mus musculus [Pathway:R-RNO-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Rattus norvegicus [Pathway:R-CFA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Canis familiaris [Pathway:R-BTA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Bos taurus [Pathway:R-SSC-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Sus scrofa [Pathway:R-DRE-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Danio rerio [Pathway:R-GGA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Gallus gallus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6803204
summation	[Summation:6803210] Apoptotic transcriptional targets of TP53 include genes that...
updateTrackers	[UpdateTracker:9783222] Update Tracker - [Pathway:6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - v57:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes
(updatedInstance)	[UpdateTracker:9783222] Update Tracker - [Pathway:6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - v57:[updateContainedRLE]

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