Reactome | TP53 family members bind the BAX promoter

Schema > Reaction > Entries

TP53 family members bind the BAX promoter Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3700983] Orlic-Milacic, M, 2013-06-11
dbId	3700981
displayName	TP53 family members bind the BAX promoter
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3700984] TP53 family members stimulate BAX transcription - Homo sapiens
input	[Complex:R-HSA-6799788] (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3700977] BAX gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 family members bind the BAX promoter
output	[Complex:R-HSA-3700978] (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6799777] TP53 family members bind PPP1R13B or TP53BP2 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3700981
summation	[Summation:6799794] TP53 (p53) binds the p53 response element in the promoter of...

Referrals

(hasEvent)	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
(precedingEvent)	[BlackBoxEvent:R-HSA-3700984] TP53 family members stimulate BAX transcription

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