Reactome | ATM phosphorylates ZNF420

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ATM phosphorylates ZNF420 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6799098] Orlic-Milacic, Marija, 2015-09-21
dbId	6799097
displayName	ATM phosphorylates ZNF420
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1247509] ZNF420 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798626] Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis [LiteratureReference:6799101] KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	ATM phosphorylates ZNF420
orthologousEvent	[Reaction:R-DME-6799097] ATM phosphorylates ZNF420 - Drosophila melanogaster [Reaction:R-GGA-6799097] ATM phosphorylates ZNF420 - Gallus gallus [Reaction:R-SSC-6799097] ATM phosphorylates ZNF420 - Sus scrofa [Reaction:R-BTA-6799097] ATM phosphorylates ZNF420 - Bos taurus [Reaction:R-CFA-6799097] ATM phosphorylates ZNF420 - Canis familiaris [Reaction:R-RNO-6799097] ATM phosphorylates ZNF420 - Rattus norvegicus [Reaction:R-MMU-6799097] ATM phosphorylates ZNF420 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6799095] p-S68-ZNF420 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799097
summation	[Summation:6799094] Activated ATM phosphorylates ZNF420 (Apak) at serine residue...

Referrals

(hasEvent)

[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release