Reactome | TP53 family members stimulate BAX transcription

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TP53 family members stimulate BAX transcription Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:3700983] Orlic-Milacic, M, 2013-06-11
dbId	3700984
displayName	TP53 family members stimulate BAX transcription
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens
followingEvent	[Reaction:R-HSA-6803892] SFN dimer binds BAX - Homo sapiens [Reaction:R-HSA-168849] tBID binds to inactive BAX protein - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3700977] BAX gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 family members stimulate BAX transcription
output	[EntityWithAccessionedSequence:R-HSA-139916] BAX [cytosol]
precedingEvent	[Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-3700982] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642370] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm]' Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3700984
summation	[Summation:6799797] BAX is a member of the group of pro-apoptotic proteins posse...

Referrals

(hasEvent)	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
(precedingEvent)	[Reaction:R-HSA-6803892] SFN dimer binds BAX [Reaction:R-HSA-168849] tBID binds to inactive BAX protein

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