Reactome | ASPP proteins specifically stimulate the apoptotic function of p53

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author	[Person:6799783] Samuels-Lev, Y [Person:6799771] O'Connor, DJ [Person:6799787] Bergamaschi, D [Person:6799785] Trigiante, G [Person:6799784] Hsieh, JK [Person:3878151] Zhong, S [Person:6799789] Campargue, I [Person:6799782] Naumovski, L [Person:6799770] Crook, T [Person:2395790] Lu, X
created	[InstanceEdit:6799774] Orlic-Milacic, Marija, 2015-09-25
dbId	6799772
displayName	ASPP proteins specifically stimulate the apoptotic function of p53
journal	Mol. Cell
pages	781-94
pubMedIdentifier	11684014
schemaClass	LiteratureReference
title	ASPP proteins specifically stimulate the apoptotic function of p53
url	http://www.ncbi.nlm.nih.gov/pubmed/11684014
volume	8
year	2001

Referrals

(literatureReference)

[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes
[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors
[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
[BlackBoxEvent:R-HSA-6799441] TP53 stimulates expression of the TP53I3 (PIG3) gene
[RegulationReference:9642884] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm]' A polymorphic microsatellite that mediates induction of PIG3 by p53
[Reaction:R-HSA-6799462] TP53 family members bind the TP53I3 (PIG3) gene promoter
[BlackBoxEvent:R-HSA-3700984] TP53 family members stimulate BAX transcription
[Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter
[Reaction:R-HSA-6799777] TP53 family members bind PPP1R13B or TP53BP2
[RegulationReference:9642370] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm]' Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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