Reactome | TP53 stimulates and ZNF420 inhibits TP53AIP1 expression

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TP53 stimulates and ZNF420 inhibits TP53AIP1 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6798612] Orlic-Milacic, Marija, 2015-09-19
dbId	6798611
displayName	TP53 stimulates and ZNF420 inhibits TP53AIP1 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6798610] TP53AIP1 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798614] p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 [LiteratureReference:6798366] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage [LiteratureReference:6798626] Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates and ZNF420 inhibits TP53AIP1 expression
output	[EntityWithAccessionedSequence:R-HSA-6798613] TP53AIP1 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6798605] Positive gene expression regulation by 'p-S15,S20,S46-TP53 Tetramer:TP53AIP1 Gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-6798617] Negative gene expression regulation by 'ZNF420:TP53AIP1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641321] Positive gene expression regulation by 'p-S15,S20,S46-TP53 Tetramer:TP53AIP1 Gene [nucleoplasm]' p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 [RegulationReference:9641665] Negative gene expression regulation by 'ZNF420:TP53AIP1 Gene [nucleoplasm]' Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6798611
summation	[Summation:6798604] TP53 (p53) bound to the p53 response element in the first in...

Referrals

(hasEvent)

[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release