Reactome | Dual incision in TC-NER

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Dual incision in TC-NER Show undefined attributes

authored	[InstanceEdit:111298] Gopinathrao, G, 2004-02-11 18:33:11 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782136] Orlic-Milacic, Marija, 2015-06-04
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	6782135
deleted	[Deleted:6793378] Deletion of instance: 110304
displayName	Dual incision in TC-NER
edited	[InstanceEdit:5696396] Orlic-Milacic, Marija, 2015-05-28
eventOf	[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER) - Homo sapiens
followingEvent	[Pathway:R-HSA-6782210] Gap-filling DNA repair synthesis and ligation in TC-NER - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens [Reaction:R-HSA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens [Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens [Reaction:R-HSA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Homo sapiens [Reaction:R-HSA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Homo sapiens [Reaction:R-HSA-6782211] DNA polymerases delta, epsilon or kappa bind the TC-NER site - Homo sapiens [Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-06-17
literatureReference	[LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template [LiteratureReference:6782906] Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro [LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782727] Transcription-coupled DNA repair: two decades of progress and surprises [LiteratureReference:5690036] Coordination of dual incision and repair synthesis in human nucleotide excision repair [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:6790538] Mammalian transcription-coupled excision repair
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Dual incision in TC-NER
orthologousEvent	[Pathway:R-MMU-6782135] Dual incision in TC-NER - Mus musculus [Pathway:R-PFA-6782135] Dual incision in TC-NER - Plasmodium falciparum [Pathway:R-SCE-6782135] Dual incision in TC-NER - Saccharomyces cerevisiae [Pathway:R-SPO-6782135] Dual incision in TC-NER - Schizosaccharomyces pombe [Pathway:R-DDI-6782135] Dual incision in TC-NER - Dictyostelium discoideum [Pathway:R-CEL-6782135] Dual incision in TC-NER - Caenorhabditis elegans [Pathway:R-DME-6782135] Dual incision in TC-NER - Drosophila melanogaster [Pathway:R-GGA-6782135] Dual incision in TC-NER - Gallus gallus [Pathway:R-XTR-6782135] Dual incision in TC-NER - Xenopus tropicalis [Pathway:R-DRE-6782135] Dual incision in TC-NER - Danio rerio [Pathway:R-SSC-6782135] Dual incision in TC-NER - Sus scrofa [Pathway:R-BTA-6782135] Dual incision in TC-NER - Bos taurus [Pathway:R-CFA-6782135] Dual incision in TC-NER - Canis familiaris [Pathway:R-RNO-6782135] Dual incision in TC-NER - Rattus norvegicus
precedingEvent	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6782135
summation	[Summation:6782911] In transcription-coupled nucleotide excision repair (TC-NER)...
updateTrackers	[UpdateTracker:9777048] Update Tracker - [Pathway:6782135] Dual incision in TC-NER - v73:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9777048] Update Tracker - [Pathway:6782135] Dual incision in TC-NER - v73:[addHasEvent, updateContainedRLE]
(replacementInstances)	[Deleted:6793378] Deletion of instance: 110304
(hasEvent)	[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER)
(precedingEvent)	[Pathway:R-HSA-6782210] Gap-filling DNA repair synthesis and ligation in TC-NER

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