Reactome | 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

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5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER Show undefined attributes

authored	[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782200] DNA endonuclease activity of TC-NER incision complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782203] Orlic-Milacic, Marija, 2015-06-05
dbId	6782204
deleted	[Deleted:6793191] Deletion of instance: 109976
displayName	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-6782211] DNA polymerases delta, epsilon or kappa bind the TC-NER site - Homo sapiens
input	[Complex:R-HSA-6782142] TC-NER incision complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690036] Coordination of dual incision and repair synthesis in human nucleotide excision repair
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
orthologousEvent	[Reaction:R-MMU-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Mus musculus [Reaction:R-PFA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Plasmodium falciparum [Reaction:R-SCE-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Saccharomyces cerevisiae [Reaction:R-SPO-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Dictyostelium discoideum [Reaction:R-CEL-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Caenorhabditis elegans [Reaction:R-DME-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Drosophila melanogaster [Reaction:R-GGA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Gallus gallus [Reaction:R-XTR-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Xenopus tropicalis [Reaction:R-DRE-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Danio rerio [Reaction:R-SSC-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Sus scrofa [Reaction:R-BTA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Bos taurus [Reaction:R-CFA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Canis familiaris [Reaction:R-RNO-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Rattus norvegicus
output	[Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782204
summation	[Summation:6782201] In transcription-coupled nucleotide excision repair (TC-NER)...

Referrals

(replacementInstances)	[Deleted:6793191] Deletion of instance: 109976
(hasEvent)	[Pathway:R-HSA-6782135] Dual incision in TC-NER
(precedingEvent)	[Reaction:R-HSA-6782211] DNA polymerases delta, epsilon or kappa bind the TC-NER site